How does CBD work?

  • Effectively increases CB1 density, amplifying the effects of all cannabinoids that bind to CB1 receptors.

  • Acts as a 5-HT1a receptor agonist in the brain. This means that CBD has calming and soothing effects such as some potent analgesics, but without the side effects.

  • Acts as inverse agonist of CB2 receptors, effectively reducing the effects of cannabinoids that make CB2 receptors less responsive.

  • Acts as an antagonist for the putative GPR55 receptor, an element of the endocannabinoid system that is still being researched. (It is suggested that GPR55 may be a third type of cannabinoid receptor altogether.)

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